Maria GRIGOROIU-SERBANESCU

BIRTH DATE: JUNE 4, 1950

EDUCATION:

CURRENT POSITION:

 

OFFICE ADDRESS: Alexandru Obregia Psychiatric Hospital, Biometric Psychiatric Genetics Research Unit , Sos. Berceni 10, Postal Office 8, R-75622, Bucharest, Romania

e-mail: mserban@dnt.ro; Fax: 0040-1-330.36.36; Tel. 0040-1-332.39.29

 

HUMBOLDT FELLOWSHIP:

 

Member of The International Society of Psychiatric Genetics (1995)

Member of The International Society for the Study of Behavioral Development

(1986).

Member of the advisory board of the Romanian Journal of Medicine - Series of Neurology and Psychiatry

Member of the reviewers' board of the International Journal of Behavioral Development (Lawrence Erlbaum Publishers - London)

 

Member of the Commission for Child Psychiatry and Neurology of The Romanian College of Physicians (1998)

Member of the Romanian Medical Academy (1997)

Member of the New York Academy of Sciences (1997)

 

DONATIONS: Equipment in amount of 10,000 DM (1997)

 

 

BIOMETRIC PSYCHIATRIC GENETICS AND DEVELOPMENTAL

PSYCHOPATHOLOGY RESEARCH UNIT

ALEXANDRU OBREGIA PSYCHIATRIC HOSPITAL

CONTACT:
 Research Unit ChiefDr. Maria Serbanescu, Ph.D.
 Phone: 0040-1-332.39.29; Fax: 0040-1-400.16.22; 0040-1-336.36.36;
 e-mail: mserban@dnt.ro
 Mailing address: Alexandru Obregia Psychiatric Hospital, Sos. Berceni, 10, O.P. 8,
            R-75622, Bucharest, Romania
PRESENTATION:  Web site: http://www.dnt.ro/users/mserban

Results of research on bipolar disorder published in American Journal of Medical Genetics - Neuropsychiatric Genetics, British Journal of Psychiatry, Acta Psychiatrica Scandinavica, Journal of Affective Disorders, Psychiatric Genetics, Journal of Youth and Adolescence . (See attached list of representative publications.)

Type and field of activities:

Research in: biometric psychiatric genetics (genetic epidemiology) and child and adolescent developmental psychopathology

Main recent five representative research projects:

1. Parent-of-origin and segregation models in bipolar (manic-depressive) disorder.
2. Familial aggregation patterns in bipolar disorder with young onset and genetic anticipation.
3. Precursors of major affective disorders (offspring of affectively ill parents).
4. Familial psychopathology, comorbidity and outcome in  Anorexia Nervosa with young onset.
5. Personality disorders in Anorexia Nervosa with young onset.

COLLABORATION:
Research interests in key words: clinical psychiatric genetics; bipolar disorder; eating disorders; developmental psychopathology

Key Actions in Fifth Framework Program:

b) Research and technological development activities of a generic nature:

• Research into genomes and diseases of genetic origin

• Neurosciences
.
 
 
 
 
Main publications:

a) Bipolar Disorder:

1. Serbanescu-Grigoroiu M., Martinez M., Nöthen M.M., Propping P., et al., Patterns of parental transmission and familial aggregation models in bipolar affective disorder.  American Journal of Medical Genetics - Neuropsychiatric Genetics, 81, 397-404, 1998.
2. Serbanescu-Grigoroiu M., Wickramaratne P.J., Hodge S.E., et al., Genetic anticipation and imprinting in bipolar I illness. The British Journal of Psychiatry, 170, 162-166, 1997.
3. Serbanescu-Grigoroiu M., Nöthen M.,  Propping P., Poustka F., et al.  Clinical evidence for genomic imprinting  in the bipolar I  disorder, Acta  Psychiatrica Scandinavica, 1995, 92, 365-370.
4. Serbanescu-Grigoroiu, M.,  Bipolar disorder - an imprinted disorder ?, in Poustka, F., Basic Approaches to Genetic and Molecular Biological Developmental Psychiatry, Quintessenz Verlag, München-London-Chicago, 1994, 139-153.
5. Serbanescu-Grigoroiu M., Christodorescu D., Magureanu S., et al.., Adolescent  offspring of endogenous unipolar depressive parents and of normal parents, Journal of Affective Disorders, 21, 1991,  185-198 .
6. Serbanescu-Grigoroiu M., Christodorescu D., Totoescu A., et al., Depressive disorders and depressive personality traits in offspring aged 10-17 of bipolar I and normal parents, The Journal of Youth and Adolescence, 2, 1991,135-148.
7. Serbanescu-Grigoroiu M., Christodorescu D., Jipescu I., et al., Psychopathology in children aged 10-17 of bipolar parents: psychopathology rate and correlates of the severity of the psychopathology, Journal of Affective Disorders, 16, 1989, p. 167-179.

 b) Eating Disorders:

1. Serbanescu-Grigoroiu M., Milea S., Magureanu S., Marinescu E., Long-term follow-up of anorexia nervosa with adolescent onset. Comorbidity and familial psychopathology. Romanian Journal Neurology, 36, 1-2, 1998, 63-73.
2. Steinhausen H-CH., Bojadieva S., Serbanescu-Grigoroiu M., The International Collaborative Outcome Study of Adolescent Eating disorders: evaluation of treatment and outcome. British Journal of Psychiatry, in press .

3. Serbanescu-Grigoroiu M., Milea S., Magureanu S., Marinescu E., Lack of aggregation of eating disorders in families of young onset anorexic patients. Submitted for publication.

 

 

C.V.

1982 - Ph. D. at the University of Bucharest

1986 - member of The International Society of Behavioral Development

1987 - Prize of the Romanian Academy for research in child psychopathology (The Gheorghe Marinescu Prize)

- member of the advisory board of the Romanian Journal of Medicine - Series of Neurology and Psychiatry

1989 - scientific researcher IIIrd degree

1991-1992: Humboldt fellow at Institut für Humangenetik - Bonn and Zentrum der Psychiatrie der Goethe-Universität Frankfurt/M.

 

1995 - Member of The International Society of Psychiatric Genetics.

1995 - scientific researcher I. degree (equivalent professor)

1996 - 1997 - Humboldt fellow at Institut für Humangenetik and Psychiatrische Universitätsklinik - Bonn.

1997 - Member of the Romanian Medical Academy

1998 - Member of the Commission for Child Psychiatry and Neurology of The Romanian College of Physicians

 

 

 

Scientific travels:

-1981 - stipend for 2 months at the University of Geneva

-1987 - invited researcher at Pennsylvania State College and Educational Testing Services in Princeton (N.J.); talks at New York State Psychiatric Institute and NIMH-Bethesda.

-1990 - Gastwissenschaftler (invited researcher) at the Free University Berlin, Child Psychiatric Clinic Frankfurt/M, Technical University Darmstadt (F.R.G.)

-1992 - talks at the Psychiatric Clinic of Mainz and the Psychiatric Clinic of Frankfurt (F.R.G.)

-1994 - talks at the Psychiatric Clinics of Stuttgart, Ulm and Heidelberg (F.R.G.);

- 1995 - talks at Columbia University (New york), Yale University (New Haven); Harvard

University (Boston), National Institute of Mental Health (Washington), INSERM (Paris).

- 1996 - 1997 - talks at Psychiatrische Klinik Zürich, Insitut für Humangenetik - Bonn, Psychiatrische Klinik der Universität Bonn.

 

 

Congress participations:

1977 - Conference on developmental psychology in Prague (Czechoslovakia); 1978 - International Congress of Applied Psychology in Munich (F.R.G.); 1979 - International Congress of

Child Psychology in Paris; 1981 - Conference on Developmental Psychology in Augsburg (F.R.G.); 1986 - Summer School of the International Society for the Study of Behavioral Development in Prague; 1987 - workshop on the Emergence of depression in adolescence in Princeton (N.J.); 1987 - International Congress of Child and Adolescent Psychiatry in Varna (Bulgaria); 1988 -European Conference on Developmental Psychology in Budapest (Hungary); 1989 - World Congress of Psychiatry in Athens (Greece); 1991 - International Congress

of Child and Adolescent Psychiatryin Bad Homburg/Frankfurt/M (F.R.G.); 1995 - World Congress of Psychiatric Genetics (Cardiff); 1997 - World Congress on Psychiatric Genetics - Santa Fe;

1998 - World Congress on Psychiatric Genetics - Bonn.

 

Foreign language competence: English, German, French

 

 

 

 

 

PUBLICATION LIST

I. PAPERS PUBLISHED IN JOURNALS AND BOOKS

 

1999:

1. SERBANESCU-GRIGOROIU M., Genetica tulburarilor anxioase, in Teodorescu R. (ed.), Actualitati in tulburarile anxioase, editura Cris, Bucuresti, 1999, p. 9-30.

1998:

2. SERBANESCU-GRIGOROIU M., MARTINEZ M., NÖTHEN M.M., PROPPING P., MILEA S., MIHAILESCU R., Patterns of parental transmission and familial aggregation models in bipolar affective disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81, 397-404, 1998 (Current Contents - Life Sciences)

3. SERBANESCU-GRIGOROIU M., MILEA S., MAGUREANU S., MARINESCU E., Long-term follow-up of anorexia nervosa with adolescent onset. Comorbidity and familial psychopathology. Romanian Journal Neurology, 36, 1-2, 1998, 63-73.

4. Steinhausen H-Ch., Bojadijeva S., Serbanescu-Grigoroiu M., The International Collaborative Outcome Study of Adolescent Eating disorders: evaluation of treatment and outcome. British Journal of Psychiatry, in press.

1997:

5. SERBANESCU-GRIGOROIU M., WICKRAMARATNE P.J., HODGE S.E., MILEA S., MIHAILESCU R., Genetic anticipation and imprinting in bipolar I illness. The British Journal of Psychiatry, 170, 162-166, 1997 (Current Contents - Life Sciences).

6. SERBANESCU-GRIGOROIU M., Genetica clinico-biometrica a tulburarilor psihice majore. In Teodorescu R., Mihailescu M. (ed.) Sanatatea mintala. Conceptii actuale. Ed. National, Bucuresti.

1996:

7. SERBANESCU-GRIGOROIU M., WICKRAMARATNE P.J., HODGE S.E., Genetic anticipation in bipolar I illness. Romanian Journal of Neurology and Psychiatry, 34, 1-2, 1996.

8. SERBANESCU-GRIGOROIU M., Genetica depresiei unipolare. Sinapse,

1995:

9. SERBANESCU-GRIGOROIU M., NOTHEN M., PROPPING P., POUSTKA F., MAGUREANU S., VASILESCU R., MARINESCU E., ARDELEAN V., Clinical evidence for genomic imprinting in the bipolar I disorder, Acta Psychiatrica Scandinavica, 1995, 92, 365-

370 ( Current Contents - Life Sciences ).

10. SERBANESCU M., WICKRAMARATNE P., HODGE S. E., Age of onset and current age in the estimation of genetic anticipation in bipolar I illness, Psychiatric Genetics, 5, 1995, 10 .

1994:

11. SERBANESCU-GRIGOROIU, M., Bipolar disorder - an imprinted disorder ?, in POUSTKA, F., BASIC APPROACHES TO GENETIC AND MOLECULAR BIOLOGICAL DEVELOPMENTAL PSYCHIATRY, Quintessenz Verlag, München-London-Chicago, 1994, 139-153.

12. SERBANESCU-GRIGOROIU M., Current genetic models of primary affective disorders, Romanian Journal of Neurology and Psychiatry, 32, 1, 1994, 29-42.

13. SERBANESCU-GRIGOROIU M., An overview of clinical and psychological research findings in anorexia nervosa, Romanian Journal of Neurology and Psychiatry, 32, 4, 1994, 219-230.

1993:

14. SERBANESCU-GRIGOROIU M., Kinder psychisch kranker Eltern (Children of mentally disordered parents), in MARKEFKA M, NAUCK B.(Eds.), HANDBUCH DER KINDHEITSFORSCHUNG (Handbook of childhood research), Luchterhand Verlag, Bonn-Neuwied,1993, 649-663.

15. SERBANESCU-GRIGOROIU M., MAGUREANU S., Anorexie und Perönlichkeitsstörung im Verlauf der Erkrankung (Personality disorder in the course of anorexia ) , in POUSTKA F., LEHMKUHL U.,(Eds.), Gefährdung der kindlichen Entwicklung, Quintessenz Verlag, München-London-Chicago,1993, 151-158.

16. SERBANESCU-GRIGOROIU M., Genomic imprinting and fragile X-syndrome in psychiatric disorders, Rom. J. Neurology and Psychiatry, 1, 1993, 3-10.

1992:

17. SERBANESCU-GRIGOROIU M., Doing research in Rumania on the inheritance of depression, in BJORKLUND D. and BJORKLUND B. (Eds.), LOOKING AT CHILDREN. AN INTRODUCTION TO CHILD DEVELOPMENT Brooks/Cole Publishing Company ,Pacific Grove, California, 64-67.

18. SERBANESCU-GRIGOROIU M., A trial to apply the concept of imprinting to the manic-depressive illness, The Romanian Journal of Neurology and Psychiatry, 30, 4, 1992, 265-277.

19. SERBANESCU-GRIGOROIU M., Development of Psychology in Romania, in Sexton-Staudt V. and Hogan D. J. (Eds.), International Psychology. Views from around the World, University of Nebraska Press, Lincoln & London, 1992, p. 347-352.

3

 

1991:

20. SERBANESCU-GRIGOROIU M., Christodorescu D., Magureanu S., Jipescu I, Totoescu A., Marinescu E., Ardelean V., Popa S., Adolescent offspring of endogenous unipolar depressive parents and of normal parents, Journal of Affective Disorders, 21, 1991, p. 185-198 (Elsevier, Amsterdam)(Current Contents-Life Sciences)

21. SERBANESCU-GRIGOROIU M., Christodorescu D., Totoescu A., Jipescu I., Marinescu E., Ardelean V., Depressive disorders and depressive personality traits in offspring aged 10-17 of bipolar I and normal parents, The Journal of Youth and Adolescence, 2, 1991,135-148 (New York, Plenum Press) (Current Contents-Behavioral Sciences)

22. MAGUREANU S., Serbanescu-Grigoroiu M., Recent trends in the treatment of neuroses (Actualitati in terapia nevrozelor), Neurologia, Psihiatria, Neurochirurgia (Neurology, Psychiatry, Neurosurgery) (Bucharest), 1-2, 1991, p. 10-21.1990:

23. SERBANESCU-GRIGOROIU M., Christodorescu D., Jipescu I., Totoescu A., Marinescu E., Ardelean V., Children aged 10-17 of endogenous unipolar depressive parents and of normal parents. I. Psychopathology rate and relationship of the severity of the psychopathology to familial and environmental variables, Rom. J. Neurology and Psychiatry, 1, 1990, p. 45-62.

24. SERBANESCU-GRIGOROIU M., Restrictive abortion and the child mental health, Entre Nous (WHO Journal), 6, 1990, Copenhagen.

1989:

25. SERBANESCU-GRIGOROIU M., Christodorescu D., Jipescu I., Totoescu A., Marinescu E., Ardelean V., Psychopathology in children aged 10-17 of bipolar parents: psychopathology rate and correlates of the severity of the psychopathology, Journal of Affective Disorders, 16, 1989, p. 167-179, (Current Contents, Life sciences), (Elsevier, Amsterdam).1989:

26. SERBANESCU-GRIGOROIU M., A scale for assessing the severity of psychopathology in children, Rom. J. Neurology and Psychiatry, 3, 1989 p. 201-206.

1987:

27. SERBANESCU-GRIGOROIU M., A brief inventory for assessing personality traits and disorders in children aged 8-11, Rom. J. Neurology and Psychiatry, 1, 1987, p. 41-55.

28. SERBANESCU-GRIGOROIU M., Christodorescu D., Totoescu A., Jipescu I., Marinescu E., Ardelean V., Psychopathology in children

aged 10-17 of bipolar parents: psychopathology rate and correlates of the severity of the psychopathology, Rom. J. Neurology and Psychiatry, 3, 1987, p. 197-210.

4

 

1986:

29. CHRISTODORESCU D., SERBANESCU-GRIGOROIU M., The prevalence of mild mental retardation in 6-15 year old children, Rom. J. Neurology and Psychiatry, 3, 1986, p. 161-166.

30. SERBANESCU-GRIGOROIU M., Factor structure and validation of the Junior Eysenck Personality Questionnaire based on a Rumanian sample, International Journal of Psychology, 21, 1986, p 141-151 (Elsevier, Amsterdam) (Current Contents-Behavioral Sciences)

1984:

31. SERBANESCU-GRIGOROIU M., Intellectual and emotional development and school adjustment in preterm children at 6 and 7 years of age. Continuation of a follow-up study, International Journal of Behavioral Development, 7, 1984, p. 307-32o, (Elsevier, Amsterdam) (Current Contents-Behavioral Sciences).

1983:

32. SERBANESCU-GRIGOROIU M., Clinical validity of Eysenck Personality Questionnaire (Junior), Rom. J. Neurology and Psychiatry, 1, 1983, p. 43-52.

1981:

33. SERBANESCU-GRIGOROIU M., Personality inventory for psychopathological use, Rom. J. Neurology and Psychiatry, 1, 1981, p. 53-65.

34. SERBANESCU-GRIGOROIU M., Intellectual and emotional development in premature children from 1 to 5 years, International Journal of Behavioral Development, 2, 1981, p. 183-199 (Elsevier, Amsterdam) (Current Contents-Behavioral Sciences).

1979:

35. GRIGOROIU M., MIHAILESCU L., Operational strategies in the thinking of aphasics and in patients with right hemisphere lesions, Rom. J. Neurology and Psychiatry, 3, 1979, p. 293-3021978

36. GRIGOROIU M., Un instrument de mesure de la maturite' emotionnelle de l`enfant de 5 a 7 ans, Enfance (Paris), 1, 1978, 53-65.

1977:

37. GRIGOROIU M, Un inventar de dezvoltare afectiva a copilului prescolar, Revista de Psihologie, 4, 1977, p. 507-519, 1976.

38. PREDESCU V., GRIGOROIU M., Aspects of the personality of young suicide attempters, Rom. J. Neurology and Psychiatry, 3, 1976, p. 203-209.

1975:

 

 

 

5

 

39. MACADZIOB D., GRIGOROIU M., Un model al conduitei afective a copilului intre 5 si 7 ani, Revista de Psihologie, 4, 1975, p. 447-458.

40. Christodorescu D., Serbanescu-Grigoroiu M. et al., Frequency of psychic and neuropsychic disorders in children and adolescents from 1 to 16 years of age in Romania, Neurologia si Psihiatria (Neurology and Psychiatry), 1, 1984, Bucharest.

 

II. ABSTRACTS PUBLISHED IN CONGRESS VOLUMES

 

1. Serbanescu-Grigoroiu M., Magureanu S., Milea S., No familial aggregation of eating disorders in relatives of restrictive anorexic probands, 11th International Congress of the European Society for Child and Adolescent Psychiatry, Hamburg, 15-19 September 1999.

2. Serbanescu-Grigoroiu M., Magureanu S., Marinescu E., Milea S., A family study of restrictive anorexia nervosa with adolescent onset, Barcelona, 1999

3. Serbanescu-Grigoroiu M., Martinez M., Nöthen M.M., Propping P., Sex of transmitting parent and genetic models of bipolar I disorder. XI World Congress of Psychiatry, Hamburg, August 6-11, 1999.

4. Serbanescu-Grigoroiu M., Martinez M., Nöthen M.M., Propping P., Segregation models and parental transmission in bipolar I disorder, Am. J. Medical Genetics - Neuropsychiatric Genetics, 81, 6, 465-466, 1998

5. Serbanescu-Grigoroiu M., Nöthen M.M., Propping P., Maternal and Paternal transmission of bipolar disorder in a randomly selected sample of bipolar families. World Congress on Psychiatric Genetics, Santa Fe, 19-23 Oct., 1997.

6. Serbanescu-Grigoroiu M., Milea S., Magureanu S., Axis I and Axis II comorbidity in anorexia nervosa with young onset. Third London Conference on Eating Disorders, 15-17 April, 1997.

7. Serbanescu-Grigoroiu M., Psychiatric Research in Romania, X World Congress of Psychiatry, Madrid, 1996

8. SERBANESCU M., NÖTHEN M., PROPPING P., POUSTKA F. , Paternal imprinting in the bipolar I disorder, Psychiatric Genetics, 5, 1995, p. 92 (World Congress of Psychiatric Genetics, Cardiff, 1995).

9. SERBANESCU M., MAGUREANU S. Personality and outcome in anorexia nervosa, International Conference on Eating Disorders, New York, 1994, p. 162.

10. SERBANESCU M., MAGUREANU S., Adult outcome of psychotic disorders with adolescent onset, International Congress of Psychopathology, Timisoara, 1994.

11. SERBANESCU-GRIGOROIU M., Unclear support for the imprinting hypothesis in the manic-depressive disorder, World Congress of Psychiatric Genetics, New Orleans, 1993.

12. SERBANESCU-GRIGOROIU, M., NÖTHEN, M., Testing the hypothesis of imprinting in the bipolar (manic-depressive) disorder, 6th European Health Psychology Society Conference, Leipzig, 1992.

13. SERBANESCU-GRIGOROIU M., Magureanu S., Personality and outcome in anorexia nervosa with early onset, Internationaler Kongress für Kinder und Jugendpsychiatrie, Bad Homburg-Frankfurt/M, 1991.

14. SERBANESCU-GRIGOROIU M., Children aged 10-17 of parents with primary affective disorders and of normal parents: psychopathology in relationship with genetic and familial environmental factors, in Stefanis C.N., Soldatos C.R., Rabavilas A.D. (eds.), Psychiatry Today, VIII World Congress of Psychiatry, Athens, 1989, Excerpta Medica.

15. SERBANESCU-GRIGOROIU M., CHRISTODORESCU D., JIPESCU I., Interaction of genetic and environmental factors in the psychopathology of children aged 10-17 of affectively ill

parents, Tenth Biennal Meetings of the International Society for the Study of Behavioral Development, Jyüvasküla 1989.

16. SERBANESCU-GRIGOROIU M., Psychopathology and adaptive functioning in offspring of affectively ill and normal parents, The IIIrd European Conference on Developmental Psychology, Budapest, 1988.

17. SERBANESCU-GRIGOROIU M., Psychopathology rate in children of bipolar I and of normal parents, Workshop on the Emergence of Depression in Adolescence, Princeton, N.J., 1987.

18. SERBANESCU-GRIGOROIU M., Magureanu S., Long term outcome and personality structure in anorexia nervosa.Preliminary Findings. The VII European Congress of Child Psychiatry, Varna, 1987.

19. SERBANESCU-GRIGOROIU M., Developmental psychopathology and some statistical issues related to the determination of psychopathology rates, II European Conference on Developmental Psychology, Roma, 1986.

20. SERBANESCU-GRIGOROIU M., Personality and cognitive psychopathology n children of bipolar parents, The IIIrd International Summer School of The International Society for the Study of Behavioral Development, Prague, 1986.

21. SERBANESCU-GRIGOROIU M., An inventory for assessing personality traits in children aged 8-11, The XXII International Congress for Applied Psychology, Jerusalem, 1986.22. SERBANESCU-GRIGOROIU M., A short adult personality inventory for psychopathologic use, The XXI International Congress of Applied Psychology, Edinburgh, 1982.

23. SERBANESCU-GRIGOROIU M., Die psychomotorische Entwicklung der

frühgeborenen Kinder von 1. bis 7. Lebensjahre und ihre Schulanpassung, in Oerter R. (Ed.), Bericht über die V. Tagung Entwicklungspsychologie, Band II, Dokumentation der Universität Augsburg (B.R.D.), 1981.

24. GRIGOROIU M., L'evolution de la reactivite socio-emotionnelle des enfants des enfants prematures de 1 a 4 ans, Congres

International de Psychologie et Psychobiologie de l'Enfant, Paris, 1979.

25. GRIGOROIU M., Ein Inventar für die affektiv-motivationale Entwicklung des Kindes zwischen 5 und 7 Jahren und seine Anwendbarkeit auf die Prognose der Schulanpassung , International Congress of Applied Psychology, München, 1978.